Antifungal activity of flavonoids and modulation of expression of genes of fatty acid synthesis in the dermatophyte Trichophyton rubrum
نویسندگان
چکیده
Background Dermatophytosis are fungal infections caused by keratinophilic fungi known as dermatophytes and classified in three genera: Trichophyton, Epidermophyton and Microsporum. Trichophyton rubrum is the most frequent species associated to dermatophytosis worldwide [1]. The infections caused by dermatophytes are not lethal, but are difficult to treat and uncomfortable. In the case of T. rubrum, they tend to be chronic, and although the superficial infections are more common, cases of deep infection have been reported in immunocompromised patients [2][3]. The number of antifungal drugs are still limited, and the acquired resistance for some of clinical antifungal have been shown as well as the side effects that have been promoted by them. Reasons for the challenge in development of new antifungal drugs are the similarities shared by fungal and mammalian cells and the lack of knowledge about the biology of these pathogens. Recent evidences have shown that the fatty acid sinthase (FAS) is an interesting antifungal target [4] because of marked differences between human and fungal cells. The aim of this study was to evaluate the antifungal activity of four flavonoids described as FAS inhibitors and verify the modulation of genes in the pathway of fatty acid synthesis in T. rubrum growth in presence of the most effective one as FAS inhibitor.
منابع مشابه
Effect of chalcones in the modulation of Trichophyton rubrum cell wall synthesis genes
Background Trichophyton rubrum is a dermatophyte that causes mostly superficial mycoses in skin, hair and nails, but an invasive course has been described in immunocompromised patients [1]. The resistance to usual antifungal drugs has been observed in T.rubrum what drives an increasing demand for new antifungal drugs. Chalcones are flavonoids found in plants that exhibit pronounced antifungal a...
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BACKGROUND Fatty acid synthase (FAS) is a promising antifungal target due to its marked structural differences between fungal and mammalian cells. The aim of this study was to evaluate the antifungal activity of flavonoids described in the scientific literature as FAS inhibitors (quercetin, trans-chalcone, ellagic acid, luteolin, galangin, and genistein) against the dermatophyte Trichophyton ru...
متن کاملAuthor's response to reviews Title: The in vitro antifungal activity of flavonoids against Trichophyton rubrum is due to the inhibition of fatty acid synthase and a reduction in ergosterol content Authors:
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Gene Expression Response of Trichophyton rubrum during Coculture on Keratinocytes Exposed to Antifungal Agents
Trichophyton rubrum is the most common causative agent of dermatomycoses worldwide, causing infection in the stratum corneum, nails, and hair. Despite the high prevalence of these infections, little is known about the molecular mechanisms involved in the fungal-host interaction, particularly during antifungal treatment. The aim of this work was to evaluate the gene expression of T. rubrum cocul...
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